ALT Telomeres Borrow from Meiosis to Get Moving
نویسندگان
چکیده
منابع مشابه
ALT Telomeres Borrow from Meiosis to Get Moving
Telomere clustering is required for the homologous recombination events that maintain chromosome ends in cells relying on alternative lengthening of telomeres (ALT). New data demonstrate that damage signaling at telomeres, a likely step in activating maintenance mechanisms, induces directional movement and synapsis driven by the machinery responsible for recombination in meiosis.
متن کاملALT Telomeres Get Together with Nuclear Receptors
Nuclear receptors bind chromosome ends in "alternative lengthening of telomeres" (ALT) cancer cells that maintain their ends by homologous recombination instead of telomerase. Marzec et al. now demonstrate that, in ALT cells, nuclear receptors not only trigger distal chromatin associations to mediate telomere-telomere recombination events, but also drive chromosome-internal targeted telomere in...
متن کاملAnchored telomeres get longer
T wo groups conclude that factors near telomeres alter the telomeres' nuclear positioning and thus their length. The lengths of telomeres, which are caps for chromosome ends, are kept consistent by a pathway that " counts " the number of Rap1 molecules bound to telomeres. This pathway signals through Tel1 to recruit the lengthening telomerase enzyme. Cells missing Tel1 have shorter but stable t...
متن کاملSMARCAL1 Resolves Replication Stress at ALT Telomeres
Cancer cells overcome replicative senescence by exploiting mechanisms of telomere elongation, a process often accomplished by reactivation of the enzyme telomerase. However, a subset of cancer cells lack telomerase activity and rely on the alternative lengthening of telomeres (ALT) pathway, a recombination-based mechanism of telomere elongation. Although the mechanisms regulating ALT are not fu...
متن کاملThe meiosis-specific modification of mammalian telomeres
During meiosis, rapid chromosome movements within the nucleus enable homologous chromosomes to acquire physical juxtaposition. In most organisms, chromosome ends, telomeres, tethered to the transmembrane LINC-complex mediate this movement by transmitting cytoskeletal forces to the chromosomes. While the majority of molecular studies have been performed using lower eukaryotes as model systems, r...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cell
سال: 2014
ISSN: 0092-8674
DOI: 10.1016/j.cell.2014.09.013